When you say large speakers we can make the assumption this means speakers with good bass extension. The issue with these in smaller rooms is that the can overload the room with bass nodes. Too many variables to predict how any speaker will interact with the room depending on placement, true bass extension, ported vs sealed, etc. Some "large" speakers have very tight bass and some "small" speakers have a mid-bass bump that might be even worse in a smaller room. Sadly, only way to know for sure is to try them. But in general larger speakers are designed for larger rooms. I recently saw some info on Focal's website about the proper room size range (in cubic meters as I recall) for some of their models that I found helpful. Might make a good rule of thumb even for other speaker designs.
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