This is a complicated question in my opinion. I have never found a single network device that made an obvious difference.
However, combining several changes in my network chain DID make an appreciable difference. The EtherRegen was part of that upgrade.
So, anyone who is wondering about this should read up on improving your whole chain - your network throughput starting at the modem, switches, fiber, some kind of filter like the EtherRegen or GigaFoil, better ethernet cables than freebies, etc.
I found that running fiber to my Etherregen from my main switch and then using an AQ Diamond ethernet from the EtherRegen to my network DAC was all very worthwhile.
YMMV.
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