I am using my system just like you do. I have been asking myself that same question but my screen was there before I got my system up and running so I never experienced without it. I would assume it could impact with back reflections in some sort but there are so many things that can come into play before worrying about this. In my room I don't feel it as detrimental at all. I have a 106" Draper fixed screen as shown in the picture.
However, I tried a credenza for stylin' not long ago which was 24" away from the wall and this had an adverse effect on the sound as the back panel was vibrating and causing bass bloat. I sold it and kept my VTI rack. Eventually I plan to keep the amplifier alone in the middle and move the rack on the side (as shown in the mock up picture).
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